Antibiotika forstyrrer normal bakteriell kolonisering av nyfødte. Langvarig antibiotikabruk nyfødtperioden er assosiert med økt risiko for seinere infeksjon, ekrotiserende enterokolitt, død og kan ha andre langtidseffekter.
Referanser
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- Cotten CM et al. Prolonged Duration of Initial Empirical Antibiotic Treatment Is Associated With Increased Rates of Necrotizing Enterocolitis and Death for Extremely Low Birth Weight Infants. Pediatrics 2009; 123:58-66.
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- Esaiassen E et al. Antibiotic exposure in neonates and early adverse outcomes: a systematic review and meta-analysis. J Antimicrob Chemother 2017; 72: 1858-70.